Nitrate tolerance impairs nitric oxide-mediated vasodilation in vivo
نویسندگان
چکیده
منابع مشابه
Nitrate tolerance impairs nitric oxide-mediated vasodilation in vivo.
OBJECTIVES Nitroglycerin (NTG) is metabolized to nitric oxide (NO) in vascular smooth muscle cells. It is currently not clear whether prolonged exposure to NTG and tolerance development directly affects endogenous NO-mediated vasodilation in vivo. This study investigates NO-mediated vasodilation in conscious chronically catheterized rats before and after development of nitrate tolerance. The ef...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 1996
ISSN: 0008-6363
DOI: 10.1016/s0008-6363(96)00027-2